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کنترل بهینه لیزر در درمان حرارتی سرطان | ||
| نشریه مهندسی مکانیک امیرکبیر | ||
| مقاله 7، دوره 54، شماره 10، دی 1401، صفحه 2333-2350 اصل مقاله (3.48 M) | ||
| نوع مقاله: مقاله پژوهشی | ||
| شناسه دیجیتال (DOI): 10.22060/mej.2022.20946.7344 | ||
| نویسندگان | ||
| سجاد صمدی؛ مصطفی نصیری* ؛ مرضیه رضازاده | ||
| دانشکده فنی مهندسی گلپایگان، دانشگاه صنعتی اصفهان، ایران | ||
| چکیده | ||
| درمان حرارتی یکی از روش‌های درمان سرطان است که عملکرد آن به کنترل دقیق توزیع دما درون بافت آسیب دیده بستگی دارد. در روش درمان حرارتی، افزایش دما در بافت سالم مجاور بافت آسیب دیده می‌تواند عوارض ناگواری داشته باشد. در این مقاله، کنترل بهینه لیزر به منظور درمان حرارتی سرطان با به حداقل رساندن آسیب حرارتی انجام می‌شود. با توجه به رفتار غیرفوریه‌ای انتقال حرارت در درمان تحت لیزر، توزیع دمای گذرای وابسته به زمان در حالت یک بعدی، به همراه گرمای متابولیسم و پرفیوژن خون با استفاده از معادله انتقال حرارت پنز بررسی می‌گردد. سپس برای به حداقل رساندن آسیب حرارتی درون بافت سالم مجاور بافت آسیب دیده، تابع هدفی شامل اختلاف آسیب حرارتی محاسبه شده با آسیب حرارتی مطلوب درنظر گرفته می‌شود. برای حل مسئله کنترل بهینه، از روش گرادیان مزدوج استفاده شده است. شرایط مرزی بافت مورد نظر در سطح پوست به صورت همرفت و در عمق بافت به صورت دما ثابت و برابر دمای خون در نظر گرفته شده است. نتایج حاصل از حل مسئله کنترل بهینه نشان می‌دهد که آسیب حرارتی با در نظر گرفتن شار حرارتی مثلثی با خطای 2% و با شار حرارتی پله‌ای با خطای 5% منطبق با آسیب حرارتی مطلوب است. | ||
| کلیدواژه‌ها | ||
| کنترل بهینه؛ درمان حرارتی؛ سرطان؛ آسیب حرارتی؛ گرادیان مزدوج | ||
| عنوان مقاله [English] | ||
| Optimal laser control for cancer thermal therapy | ||
| نویسندگان [English] | ||
| Sajjad Samadi؛ Mostafa Nasiri؛ Marzieh Rezazadeh | ||
| Mechanical Engineering Group, Golpayegan College of Engineering, Isfahan University of Technology | ||
| چکیده [English] | ||
| Todays, various treatments such as surgery, chemotherapy, radiotherapy, and hyperthermia are used to treat cancer. The best treatment for cancer is to accurately control the distribution of temperature in the damaged tissue, which has been the subject of many studies in recent years. Due to the increased temperature in cancer treatment, and especially in hyperthermia, the healthy tissue adjacent to the damaged tissue also disappears and results in bad consequences. In this paper, the optimal laser control for cancer therapy has been done. According to the non-Fourier behavior of temperature transitions in laser treatments, the time-dependent transient temperature distribution in one-dimensional mode, along with the heat of metabolism and perfusion of blood, using the Pence heat transfer equation, is analyzed. In order to minimize the damage to the healthy tissues adjacent to the damaged tissue, the objective function includes the difference between the calculated thermal damage with the desired thermal damage is defined. Therefore, the thermal flux value is optimized as an optimal control problem, and the lowest and most useful value is obtained. Finally, the results of the numerical solution to this problem are extracted and shown for triangular thermal flux and square heat pulses. | ||
| کلیدواژه‌ها [English] | ||
| Optimal control, Hyperthermia, Tumor, Thermal damage, Conjugate gradient | ||
| مراجع | ||
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