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Prediction of Flow Behavior and Level of Hemolysis in a Pulsatile Left Ventricular Assist Device | ||
| AUT Journal of Mechanical Engineering | ||
| مقاله 1، دوره 4، شماره 4، اسفند 2020، صفحه 427-434 اصل مقاله (1.19 M) | ||
| نوع مقاله: Research Article | ||
| شناسه دیجیتال (DOI): 10.22060/ajme.2020.16951.5843 | ||
| نویسندگان | ||
| amir hossein Vakilzadeh؛ Kourosh Javaherdeh* | ||
| University of Guilan | ||
| چکیده | ||
| Heart failure claims the lives of thousands of people annually. Left ventricular assist device is a valid treatment option for patients with an advanced stage of heart failure. The left ventricular assist device is a blood pump increasing the pumping ability of the bottom left chamber of the patient's heart. In this study, we investigate the hemolytic characteristics of a left ventricular assist device. The main objective of this paper is to explore the effects of amplitude and frequency on levels of hemolysis via computational fluid dynamic in an implantable reciprocating pump. Thus, the dynamic mesh technique is utilized to simulate piston motion and valves closure. Moreover, a system of time-dependent nonlinear partial differential equations is coupled with each other to predict blood flow and hemolysis index. Fluid dynamic characteristics are obtained by employing continuity and momentum equations and the levels of hemolysis are also calculated by applying two additional scalar transport equations based on an Eulerian transport approach. The results depicted the favorable reduction in hemolysis index by increasing frequency and decreasing amplitude simultaneously at specific Reynolds number, they also showed that the average hemolysis at the right side of the piston is slightly higher than the left side and it obtains its maximum value at valves and clearance domains. | ||
| کلیدواژه‌ها | ||
| Left ventricular assist device؛ Blood pump؛ Hemolysis؛ Eulerian transport approach؛ Dynamic mesh | ||
| مراجع | ||
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[1] M. Alizadeh, S. Rahmani, P. Tehrani, Calculating the aortic valve force and generated power by a specific cardiac assist device (AVICENA) in different counterpulsation, Journal of the Brazilian Society of Mechanical Sciences and Engineering, 40(6) (2018) 286. [2] J. Garbade, H.B. Bittner, M.J. Barten, F.-W. Mohr, Current trends in implantable left ventricular assist devices, Cardiology research and practice, 2011 (2011). [3] A.T. Tzallas, N.S. Katertsidis, E.C. Karvounis, M.G. Tsipouras, G. Rigas, Y. Goletsis, K. Zielinski, L. Fresiello, A. Di Molfetta, G. Ferrari, Modeling and simulation of speed selection on left ventricular assist devices, Computers in biology and medicine, 51 (2014) 128-139. [4] K. Fraser, M. Taskin, T. Zhang, B. Griffith, Z. Wu, Comparison of shear stress, residence time and lagrangian estimates of hemolysis in different ventricular assist devices, in: 26th Southern Biomedical Engineering Conference SBEC 2010, April 30-May 2, 2010, College Park, Maryland, USA, Springer, 2010, pp. 548-551. [5] C. Long, M. Esmaily-Moghadam, A. Marsden, Y. Bazilevs, Computation of residence time in the simulation of pulsatile ventricular assist devices, Computational Mechanics, 54(4) (2014) 911-919. [6] S. Rahmani, M. Navidbakhsh, M. Alizadeh, Investigation of a new prototype of multi-balloons LVAD using FSI, Journal of the Brazilian Society of Mechanical Sciences and Engineering, 40(1) (2018) 8. [7] J.N. Kirkpatrick, G. Wieselthaler, M. Strueber, M.G.S.J. Sutton, J.E. Rame, Ventricular assist devices for treatment of acute heart failure and chronic heart failure, Heart, 101(14) (2015) 1091-1096. [8] C.A. Thunberg, B.D. Gaitan, F.A. Arabia, D.J. Cole, A.M. Grigore, Ventricular assist devices today and tomorrow, Journal of cardiothoracic and vascular anesthesia, 24(4) (2010) 656-680. [9] K.G. Soucy, G.A. Giridharan, Y. Choi, M.A. Sobieski, G. Monreal, A. Cheng, E. Schumer, M.S. Slaughter, S.C. Koenig, Rotary pump speed modulation for generating pulsatile flow and phasic left ventricular volume unloading in a bovine model of chronic ischemic heart failure, The Journal of Heart and Lung Transplantation, 34(1) (2015) 122-131. [10] L. Xu, M. Yang, L. Ye, Z. Dong, Computational fluid dynamics analysis and PIV validation of a bionic vortex flow pulsatile LVAD, Technology and Health Care, 23(s2) (2015) S443-S451. [11] B. Cremers, A. Link, C. Werner, H. Gorhan, I. Simundic, G. Matheis, B. Scheller, M. Böhm, U. Laufs, Pulsatile venoarterial perfusion using a novel synchronized cardiac assist device augments coronary artery blood flow during ventricular fibrillation, Artificial organs, 39(1) (2015) 77-82. [12] J. Di Paolo, J.F. Insfrán, E.R. Fries, D.M. Campana, M.E. Berli, S. Ubal, A preliminary simulation for the development of an implantable pulsatile blood pump, Advances in biomechanics and applications, 1(2) (2014) 127-141. [13] M. Behbahani, M. Behr, M. Hormes, U. Steinseifer, D. Arora, O. Coronado, M. Pasquali, A review of computational fluid dynamics analysis of blood pumps, European Journal of Applied Mathematics, 20(4) (2009) 363-397. [14] A. Schenkel, M. Deville, M. Sawley, P. Hagmann, J.-D. Rochat, Flow simulation and hemolysis modeling for a blood centrifuge device, Computers & Fluids, 86 (2013) 185-198. [15] E. Okamoto, T. Hashimoto, T. Inoue, Y. Mitamura, Blood compatible design of a pulsatile blood pump using computational fluid dynamics and computer‐aided design and manufacturing technology, Artificial organs, 27(1) (2003) 61-67. [16] M. Giersiepen, L. Wurzinger, R. Opitz, H. Reul, Estimation of shear stress-related blood damage in heart valve prostheses-in vitro comparison of 25 aortic valves, The International journal of artificial organs, 13(5) (1990) 300-306. [17] K.H. Fraser, M.E. Taskin, B.P. Griffith, Z.J. Wu, The use of computational fluid dynamics in the development of ventricular assist devices, Medical engineering & physics, 33(3) (2011) 263-280. [18] O. Myagmar, S.W. Day, The evaluation of blood damage in a left ventricular assist device, Journal of Medical Devices, 9(2) (2015) 020914. [19] H. Yu, S. Engel, G. Janiga, D. Thévenin, A review of hemolysis prediction models for computational fluid dynamics, Artificial organs, 41(7) (2017) 603-621. [20] M.E. Taskin, K.H. Fraser, T. Zhang, B. Gellman, A. Fleischli, K.A. Dasse, B.P. Griffith, Z.J. Wu, Computational characterization of flow and hemolytic performance of the UltraMag blood pump for circulatory support, Artificial organs, 34(12) (2010) 1099-1113. [21] G. Heuser, R. Opitz, A Couette viscometer for short time shearing of blood, Biorheology, 17(1-2) (1980) 17-24. [22] C. Multiphysics, Comsol multiphysics user guide (version 4.3 a), COMSOL, AB, (2012) 39-40.
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