Rouzbahani, Yashar, Kehtari, Mousa, Imani, Mahdi, Saviz, Mehrdad, Shabani, Iman, Moradikhah, Farzad, Alizadeh, Farhad, Karami, Mohammad-Hossein, Seyedjafari, Ehsan, Jooyan, Najmeh, Mostajabi, Zahra, Faraji-Dana, Reza. (1399). Study of Ultra-weak CW and Amplitude-Modulated Microwaves effects on stem Cell Proliferation: an Experimental and Hypothetical Approach. نشریه مهندسی عمران امیرکبیر, 52(1), 3-8. doi: 10.22060/eej.2020.16230.5283
Yashar Rouzbahani; Mousa Kehtari; Mahdi Imani; Mehrdad Saviz; Iman Shabani; Farzad Moradikhah; Farhad Alizadeh; Mohammad-Hossein Karami; Ehsan Seyedjafari; Najmeh Jooyan; Zahra Mostajabi; Reza Faraji-Dana. "Study of Ultra-weak CW and Amplitude-Modulated Microwaves effects on stem Cell Proliferation: an Experimental and Hypothetical Approach". نشریه مهندسی عمران امیرکبیر, 52, 1, 1399, 3-8. doi: 10.22060/eej.2020.16230.5283
Rouzbahani, Yashar, Kehtari, Mousa, Imani, Mahdi, Saviz, Mehrdad, Shabani, Iman, Moradikhah, Farzad, Alizadeh, Farhad, Karami, Mohammad-Hossein, Seyedjafari, Ehsan, Jooyan, Najmeh, Mostajabi, Zahra, Faraji-Dana, Reza. (1399). 'Study of Ultra-weak CW and Amplitude-Modulated Microwaves effects on stem Cell Proliferation: an Experimental and Hypothetical Approach', نشریه مهندسی عمران امیرکبیر, 52(1), pp. 3-8. doi: 10.22060/eej.2020.16230.5283
Rouzbahani, Yashar, Kehtari, Mousa, Imani, Mahdi, Saviz, Mehrdad, Shabani, Iman, Moradikhah, Farzad, Alizadeh, Farhad, Karami, Mohammad-Hossein, Seyedjafari, Ehsan, Jooyan, Najmeh, Mostajabi, Zahra, Faraji-Dana, Reza. Study of Ultra-weak CW and Amplitude-Modulated Microwaves effects on stem Cell Proliferation: an Experimental and Hypothetical Approach. نشریه مهندسی عمران امیرکبیر, 1399; 52(1): 3-8. doi: 10.22060/eej.2020.16230.5283

Study of Ultra-weak CW and Amplitude-Modulated Microwaves effects on stem Cell Proliferation: an Experimental and Hypothetical Approach

AUT Journal of Electrical Engineering
مقاله 1، دوره 52، شماره 1، شهریور 2020، صفحه 3-8    اصل مقاله (625.67 K)
نوع مقاله: Research Article
شناسه دیجیتال (DOI): 10.22060/eej.2020.16230.5283
نویسندگان
Yashar Rouzbahani1؛ Mousa Kehtari2؛ Mahdi Imani1؛ Mehrdad Saviz* 3؛ Iman Shabani1؛ Farzad Moradikhah1؛ Farhad Alizadeh1؛ Mohammad-Hossein Karami2؛ Ehsan Seyedjafari4؛ Najmeh Jooyan5؛ Zahra Mostajabi6؛ Reza Faraji-Dana7
1Biomedical Engineering Department, Amirkabir University of Technology (Tehran Polytechnic), Tehran, Iran
2Developmental Biology Laboratory, School of Biology, College of Science, University of Tehran, Tehran, Iran
3Biomedical Engineering Department, Amirkabir University of Technology (Tehran Polytechnic)
4Department of Biotechnology, College of Science, University of Tehran, Tehran, Iran
5Bioelectromagnetics Laboratory, School of Electrical and Computer Engineering, University of Tehran
6School of Electrical and Computer Engineering, University of Tehran, Tehran, Iran
7INSF Chair of Computational Electromagnetics and Bio-electromagnetics, School of Electrical and Computer Engineering, University of Tehran, Tehran, Iran.
چکیده
Weak microwave radiation (WMR) in our environment has raised health concerns in the public. Among those, communication frequencies are more than ever becoming widespread and their effects need thorough studies. A correct understanding of these effects in-vivo by in-vitro experiments shall preferentially use primary cells. In this study we compared non-modulated (CW) and modulated WMR exposure of biological cells in-vitro. Human ADMSC (Adipose-Derived Mesenchymal Stem Cells) were exposed to very weak non-thermal levels of microwave Electromagnetic fields at 1135 MHz ,SAR (Specific Absorption Rate) 0.002 W/kg (Watt per Kilogram) for 30 minutes daily for 4 days. A statistically significant decrease in proliferation rate of these stem cells was observed compared to the control group with no exposure. When amplitude-modulated exposure (15 Hz (Hertz) with a depth of 80%) was used with the same carrier frequency of 1135 MHz (Mega Hertz) and consistent average power, the cell numbers showed no statistically significant difference from the non-modulated exposure, but were nevertheless lower than the not-exposed control. The observed decrease in proliferation in response to -weak microwavefields supports the hypothesis that non-excitable cells, such as undifferentiated mesenchymal stem cells can interact with, and respond to weak electromagnetic radiation at communication frequencies. Possible mechanisms responsible for the observed results have been hypothesized and directions provided for future research.
کلیدواژه‌ها
Microwave EM fields؛ Stem cell؛ weak field؛ non-thermal effects؛ Proliferation
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