Kazeroni, Zeinabalsadat Sadat, Telloo, Mahshid, Farazin, Ashkan, Saber-Samandari, Saeed, Sheikhbahaei, Erfan, Kamyab-Moghadas, Bahareh, Joneidi Yekta, Hamed, Esmaeili, Saeed, Khandan, Amirsalar. (1399). A Mitral Heart Valve Prototype Using Sustainable Polyurethane Polymer: Fabricated by 3D Bioprinter, Tested by Molecular Dynamics Simulation. نشریه مهندسی عمران امیرکبیر, 5(1), 109-120. doi: 10.22060/ajme.2020.17450.5862
Zeinabalsadat Sadat Kazeroni; Mahshid Telloo; Ashkan Farazin; Saeed Saber-Samandari; Erfan Sheikhbahaei; Bahareh Kamyab-Moghadas; Hamed Joneidi Yekta; Saeed Esmaeili; Amirsalar Khandan. "A Mitral Heart Valve Prototype Using Sustainable Polyurethane Polymer: Fabricated by 3D Bioprinter, Tested by Molecular Dynamics Simulation". نشریه مهندسی عمران امیرکبیر, 5, 1, 1399, 109-120. doi: 10.22060/ajme.2020.17450.5862
Kazeroni, Zeinabalsadat Sadat, Telloo, Mahshid, Farazin, Ashkan, Saber-Samandari, Saeed, Sheikhbahaei, Erfan, Kamyab-Moghadas, Bahareh, Joneidi Yekta, Hamed, Esmaeili, Saeed, Khandan, Amirsalar. (1399). 'A Mitral Heart Valve Prototype Using Sustainable Polyurethane Polymer: Fabricated by 3D Bioprinter, Tested by Molecular Dynamics Simulation', نشریه مهندسی عمران امیرکبیر, 5(1), pp. 109-120. doi: 10.22060/ajme.2020.17450.5862
Kazeroni, Zeinabalsadat Sadat, Telloo, Mahshid, Farazin, Ashkan, Saber-Samandari, Saeed, Sheikhbahaei, Erfan, Kamyab-Moghadas, Bahareh, Joneidi Yekta, Hamed, Esmaeili, Saeed, Khandan, Amirsalar. A Mitral Heart Valve Prototype Using Sustainable Polyurethane Polymer: Fabricated by 3D Bioprinter, Tested by Molecular Dynamics Simulation. نشریه مهندسی عمران امیرکبیر, 1399; 5(1): 109-120. doi: 10.22060/ajme.2020.17450.5862

A Mitral Heart Valve Prototype Using Sustainable Polyurethane Polymer: Fabricated by 3D Bioprinter, Tested by Molecular Dynamics Simulation

AUT Journal of Mechanical Engineering
مقاله 6، دوره 5، شماره 1، بهار 2021، صفحه 109-120    اصل مقاله (1.26 M)
نوع مقاله: Research Article
شناسه دیجیتال (DOI): 10.22060/ajme.2020.17450.5862
نویسندگان
Zeinabalsadat Sadat Kazeroni1؛ Mahshid Telloo2؛ Ashkan Farazin1؛ Saeed Saber-Samandari3؛ Erfan Sheikhbahaei4؛ Bahareh Kamyab-Moghadas5؛ Hamed Joneidi Yekta3؛ Saeed Esmaeili1؛ Amirsalar Khandan* 3
1Department of Mechanical Engineering, Khomeinishahr Branch, Islamic Azad University, Isfahan, Iran
2M.D, Resident of Internal Medicine, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran
3New Technology Research Center, Amirkabir University of Technology, Tehran, Iran
4Student Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
5Department of Chemical Engineering, Shiraz Branch, Islamic Azad University, Shiraz, Iran
چکیده
Multiple diseases can cause deformities in the structure of the heart valve and the heart valve function, which leads to the patient's physical condition disorders and medical treatments like valve replacement surgery subsequently. In this case, artificial heart valves are used extensively, which generally are made of biocompatible (biologic) or metal (mechanical) materials. Thermoplastic Polyurethane is one of the best choices for the replacement of artificial heart valves due to their high mechanical stability, which makes the heart valve function last for a long-time. Therefore, the artificial heart valves were characterized by a scanning electron microscope analysis, and molecular dynamics simulation was conducted to predict the mechanical performance of the artificial heart valves in this study. Also, the tensile strength, strain at fracture, permeability, and ultimate tensile strength were evaluated to monitor the mechanical property of these novel artificial heart valves. The obtained biological and mechanical properties of the vessel showed a suitable strain percentage at the fracture point and low permeability of the saline into the vessel. Also, about 11% increase in diameter, lead to a nearly 0.09 increase in mechanical performance. Although as surface analysis indicated, the permeability of the inner and outer layer of the artificial heart valves is in the range of 20% and 25%.
کلیدواژه‌ها
Heart valve؛ disease؛ 3D bioprinter؛ Polyurethane؛ Molecular dynamics simulation
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