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شبیه‌سازی نقش درمان ضدرگ‌زایی در رفتار جریان سیال و رسانش ماکرومولکول در تومور جامد غیرهمگن | ||
| نشریه مهندسی مکانیک امیرکبیر | ||
| مقاله 2، دوره 54، شماره 7، مهر 1401، صفحه 1481-1512 اصل مقاله (2.45 M) | ||
| نوع مقاله: مقاله پژوهشی | ||
| شناسه دیجیتال (DOI): 10.22060/mej.2022.20938.7343 | ||
| نویسندگان | ||
| محیا محمدی1؛ سیروس آقانجفی2؛ مجید سلطانی* 3 | ||
| 1دانشجوی دکترا، گروه تبدیل انرژی، دانشکده مهندسی مکانیک، دانشگاه صنعتی خواجه نصیرالدین طوسی، تهران، ایران | ||
| 2استاد، گروه تبدیل انرژی، دانشکده مهندسی مکانیک، دانشگاه صنعتی خواجه نصیرالدین طوسی، تهران، ایران | ||
| 3دانشیار، گروه تبدیل انرژی، دانشکده مهندسی مکانیک، دانشگاه صنعتی خواجه نصیرالدین طوسی، تهران، ایران | ||
| چکیده | ||
| مطالعه حاضر مدل عددی مبتنی بر مدل‌های ریاضی حاکم بر رفتار جریان سیال و انتقال دارو در تومورها را توسعه می‌دهد تا به بررسی رسانش ماکرومولکول به یک تومور غیریکنواخت، شامل بخش‌های مختلف موجود در تومور جامد واقعی، تحت تأثیر هنجارسازی عروقی بپردازد. در این پژوهش اندازه تومور در بازه متفاوتی (شعاع معادل از 0/23 تا 2/79 سانتی‌متر) در نظر گرفته می‌شود. مساحت زیر نمودارهای توزیع غلظت میانگین دارو و انحراف از آن بر حسب زمان در ناحیه توموری به عنوان مقدار داروی تحویلی و یکنواختی توزیع داروی تحویلی برای بررسی کیفیت دارورسانی مطالعه می‌شوند. نتایج نشان می‌دهند که رفتار جریان سیال میان‌بافتی و توزیع غلظت عامل درمانی، قبل و بعد از هنجارسازی، به اندازه تومور وابسته می‌باشند. هنجارسازی در تمام اندازه‌ها سبب کاهش فشار سیال میان‌بافتی می‌شود که با کم شدن اندازه تومور، افت فشار ناشی از هنجارسازی افزایش می‌یابد. هنجارسازی در زمان‌های متفاوتی که وابسته به اندازه تومور است، سبب بهبود توزیع غلظت آنتی‌بادی می‌شود. با این‌حال از منظر معیارهای میانگین مکانی-زمانی، هنجارسازی عروقی در شعاع معادل از 0/46 تا 0/93 سانتی‌متر با افزایش یکنواختی توزیع، سبب بهبود رسانش ماکرومولکول به ناحیه توموری می‌شود. این پژوهش با بحث راجع به سازوکار‌های اثرگذار در کارکرد هنجارسازی می‌تواند چشم‌اندازی برای مطالعات درون‌تنی و برون‌تنی فراهم کند که از درمان ترکیبی ضدرگ‌زایی و شیمی‌درمانی بهره می‌برند. | ||
| کلیدواژه‌ها | ||
| جریان سیال؛ انتقال دارو؛ تومور غیریکنواخت؛ هنجارسازی عروقی؛ درمان ترکیبی | ||
| عنوان مقاله [English] | ||
| Simulation of the Role of the Anti-Angiogenic Therapy in Fluid Flow Behavior and Macromolecule Transport into a Heterogeneous Solid Tumor | ||
| نویسندگان [English] | ||
| Mahya Mohammadi1؛ Cyrus Aghanajafi2؛ Majid Soltani3 | ||
| 1Department of Mechanical Engineering, K. N. Toosi University of Technology, Tehran, Iran | ||
| 2Department of Mechanical Engineering, K. N. Toosi University of Technology, Tehran, Iran | ||
| 3Department of Mechanical Engineering, K. N. Toosi University of Technology, Tehran, Iran | ||
| چکیده [English] | ||
| The present study develops a numerical approach based on the mathematical models governing the behavior of fluid flow and drug transport in tumors to investigate the delivery of a macromolecule under the effect of the vascular normalization into a non-uniform tumor, including different parts of a real solid tumor. In this study, different tumor sizes in the range of are considered. The area under the curves of the drug average distribution and its deviation in the tumor site over time is studied as the amount of drug delivered and the uniformity of delivered drug to assess the quality of drug delivery. Results show that before and after normalization, the behaviors of interstitial fluid flow and the distribution of therapeutic agent concentration depend on tumor size. Normalization in all sizes reduces the interstitial fluid pressure, which this pressure drop increases as the tumor size reduces. Normalization improves antibody concentration distribution at different times depending on tumor size. However, from the point of view of the average spatiotemporal criterion, vascular normalization improves macromolecule delivery into the tumor site in by increasing the distribution uniformity. This research, by discussing the mechanisms affecting normalization efficiency, can provide insights for in vivo and in vitro studies that address the combination of anti-angiogenic therapy and chemotherapy. | ||
| کلیدواژه‌ها [English] | ||
| Fluid flow, Drug transport, Non-uniform tumor, Vascular normalization, Combo-therapy | ||
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| مراجع | ||
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